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American Diabetes Association

Previously, researchers identified oxon and thion organophosphates (OPs) degrading enzymes encoded by Plesiomonas sp

In the present study, we tested the hypothesis that NRF2 activation via dietary supplementation with Protandim would prevent salt-induced oxidative stress and endothelial dysfunction and down-regulation of the expression of two key vascular antioxidant enzymes [Cu/Zn SOD (SOD1) and Mn SOD (SOD2)] in two established animal models of pressure-independent vascular dysfunction induced by high salt diet (Sprague-Dawley rats and Syrian hamsters)

Cases of resolution and progression suggest a dynamic and reversible pathology potentially amenable to timely treatment

In aerobic organisms, the main reactive species are ROS (Halliwell and Gutteridge, 2015), but additional families include reactive nitrogen species (RNS) and reactive sulphur species (RSS), which interact with or enhance ROS generation (Figure 2)