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Description

In this study, we sought to determine how genetic ablation of the circadian clock in adipocytes exerts effects beyond the dysregulation of diet-induced thermogenesis and creatine cycling 12,13

P.CristofolettiM.OsculatiF.SbarbatiA

doi: 10.1371/journal.pone.0149557

Han JS, Kim YL, Yu HJ, et al

Participants undergo neurocognitive testing, motor examination, -synuclein skin biopsies, PET imaging with the tracers BCPP-EF, FDG, and PiB to assess mitoC1, glycolysis, and amyloid respectively, platelet bioenergetic analyses, 7T-MRI, and 7T-MRS to assess ATP, other phosphate metabolites, and lactate