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10.1038/mt.2013.190 164 WangT.LiuY.LvM.XingQ.ZhangZ.HeX.et al (2019)

[9] Many of the systemic diseases cause other symptoms apart from oral ulceration, which is in contrast to aphthous stomatitis, where there is isolated oral ulceration

This leads to changes in astrocytic glucose metabolism and glutamate transport, which in turn influence neuronal function by altering synaptic transmission and energy supply

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Atherosclerosis, a condition driven by chronic inflammation in blood vessels, may also be mitigated by zincs anti-inflammatory actions, supporting cardiovascular health by reducing the buildup of plaques in arterial walls