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Crucially, mast cell activation is intimately linked to the development of dysautonomia, particularly Postural Orthostatic Tachycardia Syndrome (POTS)

So, RBCs cannot face oxidative stress because of the insufficient glutathione synthesis and the inefficient pentose phosphate pathway to produce NADPH, which leads to the irreversible oxidation of key structural and functional proteins such as hemoglobin, band 3, and peroxiredoxin 2 (Bayer et al., 2015