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It contains a group of molecules that come from molecular oxygen, such as superoxide (O), hydrogen peroxide (H 2 O), hydroxyl radical (OH ), and peroxyl radical (RO), and the chemical reactivity of each ROS molecule is quite different (46, 47, 49)

The study utilized a model in which an AAV vector carrying a CYP46A1-specific shRNA was injected into the hippocampus of adult mice to inhibit CYP46A1 gene expression

In healthy individuals, BDNF promotes the survival and differentiation of neurons, facilitates synaptic plasticity, and enhances learning and memory processes

Thus, lipodystrophy affects not only the patients' appearance but may impact their overall health

Furthermore, the effective discrimination of AD and non-demented controls based on multiple CpG sites and RNA expression underscores the potential of DNA methylation patterns as biomarkers for AD diagnosis and prognosis (175)