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Promising therapeutic strategies include natural inhibitors (e.g., baicalin, silymarin, quercetin), pharmacological inhibitors like chlormethiazole, and gene-targeting approaches such as clustered regularly interspaced short palindromic repeat (CRISPR)-associated nuclease 9 (Cas9)-mediated knockdown in preclinical models [107, 110112]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 96.Chung A.S., Wu X., Zhuang G., Ngu H., Kasman I., Zhang J., Vernes J.M., Jiang Z., Meng Y.G., Peale F.V., et al