nnmt inhibitor clinical trial obesity 5-amino-1mq

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The Phase 2b trial (n=536, 24 weeks) did not reach its weight-loss endpoint versus placebo, and Metabolic Pharmaceuticals discontinued obesity development in 2007

That decision is made in consultation, based on the individual patients labs, history, and goals

Kim K, et al

10.2147/DMSO.S106087 163 YoshinoJ.MillsK

It is important to distinguish between excessive supplementation and pathologically elevated B12 levels, which may indicate underlying haematological disorders, liver disease, or renal impairment rather than true overdose