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Such as ferrostatin-1 and liproxstatin-1, both inhibitors work by inhibiting lipid peroxides, thereby inhibiting ferroptosis in tumor cells [188, 189]

10.1016/j.jacc.2023.04.010 33

This could be possibly attributed to the weak binding of the antioxidant components of the intact cell (IC) surface to the superoxide anion target

Conclusion In conclusion, this study demonstrates for the first time in the appropriated biological context (hypercholesterolemia) that chronic pravastatin treatment leads to liver mitochondrial redox imbalance and Ca 2+ -induced MPT

[DOI] [PubMed] [Google Scholar] 26.Brown K.H., Rivera J.A., Bhutta Z., Gibson R.S., King J.C., Lonnerdal B., Ruel M.T., Sandtrom B., Wasantwisut E., Hotz C