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Appel SH, Beers DR, Zhao W

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Serum metabolite profiling reveals metabolic characteristics of sepsis patients using LC/MS-based metabolic profiles: a cross-sectional study

Recombinant Rha1 and Rha2 metabolize 4-HNE and ectopic expression confers 4-HNE resistance to sensitive bacteria In order to determine if these putative enone reductases can directly utilize 4-HNE as a substrate, we generated recombinant Rha1 and Rha2 proteins