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Because DSIP is a small peptide that acts on the central nervous system and is degraded relatively quickly in plasma (for example, one study reported a half-life of ~78 minutes in human plasma)

10.1002/ana.10616 Ann

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Because SAM is required for hundreds of methylation reactions, including those that build creatine and glutathione, low levels of SAM can ripple across nearly every body system

The implementation of GST genotyping could identify optimal responders who would derive maximum benefit from SFN supplementation (105, 106)