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Hence, some drug development focuses on peripherally restricted KOR agonists to retain analgesic efficacy with a more favorable adverse effect [61]

Ethics declarations Conflict of interest The authors declare that there exists no competing financial interest or personal relationships that could have appeared to influence the work reported in this paper

Similarly, curcumin up-regulated the expression of miRNA-15a and miRNA-16 while suppressing anti-apoptotic protein (Bcl-2) in breast cancer cells (Yang et al., 2010)