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Several potential confounding factors should be considered when interpreting the clinical findings

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Its relevance to women's health crystallised with the finding that MOTS-c levels decline with age and estrogen depletion correlating directly with reduced skeletal muscle insulin sensitivity and visceral adiposity in postmenopausal women

[4] Researchers suggest that should Tesamorelin bind to the GHRH receptor, it may cause structural changes in the receptor, activating intracellular signaling pathways