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As suggested, LRP-1 is a multifunctional receptor expressed on glioblastoma cells and glioma-associated human endothelial cells

Regarding safety, the incidence of grade 3 peripheral sensory neuropathy for both regimens was significantly lower than historically reported rates for ixabepilone monotherapy or its combination with capecitabine

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As a result, it has a relatively low incidence of producing drowsiness compared to clonidine (Chien et al, 1990

Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation