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thus, depleted levels of Myo may cause the pathogenesis of thyroid diseases such as hypothyroidism (187)

This activation increases the transcription of MAFbx and MuRF1, enhancing the proteolytic activity of the UPS

Indeed, the majority of micropeptide-encoding regions are not conserved (Ji et al., 2015), suggesting their role in encoding evolutionary young proteins (Ruiz-Orera et al., 2014)

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I mentioned objective testing for DED, which I find helps me to diagnose the problem in detail