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High doses may lead to the K-hole phenomenon, characterized by extreme dissociation without loss of consciousness (Malhotra et al., 1996)

The relationship between B12 and bowel changes is typically indirect, relating more to the supplement formulation, excipients (inactive ingredients), or underlying health conditions rather than the vitamin itself

To reach their full anti-cancer potential, cytotoxic agents like doxorubicin, epirubicin, paclitaxel, docetaxel, cisplatin, carboplatin, antimetabolites, 5-fluorouracil, capecitabine, and targeted therapies like trastuzumab and CDK4/6 inhibitors rely on precise dosing or predictable metabolic pathways, among other factors (201)

A scalp serum may help some patients, but it should not delay a proper workup if hair loss is sudden, patchy, severe, or getting worse

Redox Signal 15 , 19571997 (2011)