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The indels identified by HaplotypeCaller command or other sites not satisfying the filtering criteria were documented as missing

It was shown to inhibit cytochrome c oxidase, leading to cell death through ATP depletion (Figure 1)

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41589_2021_915_MOESM9_ESM.mpeg Supplementary Video 7 Representative movie for 100 ns MD simulation of GPX4 U46C with the camera zoomed in for a close-up of the active site

Experimental findings further revealed that increased expression of fructose-metabolizing enzymes and fructose exposure in cardiomyocytes promoted glycolytic activity and lipid accumulation, strongly suggesting a direct role of the polyol pathway in diabetic cardiac dysfunction [24]