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The highly permeable fenestrae of the synovial capillaries allow for a bidirectional exchange of small molecules between blood and synovial fluid

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28 Furthermore, dietary fibers that act as prebiotics and induce beneficial metabolic processes and metabolites from the intestinal microbes serve potent antioxidant functionalities

Epigenetic mechanisms include DNA methylation, histone modification, and the presence of small non-coding ribonucleic acid (RNA) molecules such as micro-RNA (miRNA) that regulate the post-transcriptional expression of target genes in the oncogenic process [29]