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Samuels AL, Beesley AH, Yadav BD, Papa RA, Sutton R, Anderson D, Marshall GM, Cole CH, Kees UR, Lock RB

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Figure 4: Changes in body weight in A) lean mice and B) obese mice and changes in food intake in C) lean mice and D) obese mice, across the three different experimental treatment groups

In general, the harmful effects of excess ROS on the cell most often include damage of DNA, oxidation of polyunsaturated fatty acids (PUFA) in lipids (lipid peroxidation), oxidation of amino acids in proteins and oxidatively inactivate specific enzymes by oxidation of co-factors (Brenneisen et al., 2005