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The upregulated CD38 was also observed during the aging process, by secreted cytokines IL-6, interferons and soluble factors from senescent cells as part of so-called senescence-associated secretory phenotype (SASP) 21,27,36,47,48,49,50

Some symptoms of a vitamin B12 deficiency include: difficulty thinking brain fog fatigue pale skin weight loss dementia numbness and tingling in hands and feet mood changes decreased appetite constipation A lack of animal protein and following a plant-based diet sans appropriate supplementation can lead to a vitamin B12 deficiency

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