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Samples to undergo isocyanate addition were redissolved in 8 l buffer (100mM sodium borate and 100mM sodium phosphate pH 8.0) 1 l of a specific building block (300 mM in CH 3 CN) was added to each well and incubated at 50C for 16 hours in a in PCR-machine (Eppendorf Mastercycler Gradient)

doi: 10.1038/nature23876 90

Abstract Alzheimers disease (AD) is the most prevalent neurodegenerative disorder that predominantly affects the elderly, leading to a progressive decline in cognitive function

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