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The burden and management of cytochrome P450 2D6 (CYP2D6)-mediated drug-drug interaction (DDI): co-medication of metoprolol and paroxetine or fluoxetine in the elderly

Toxics 11 (10), 826

A justificativa para a combinao desses peptdeos reside na hiptese de que a modulao paralela da sinalizao do xido ntrico, da dinmica do citoesqueleto, da remodelao da matriz extracelular e das respostas ao estresse oxidativo pode produzir efeitos aditivos ou sinrgicos em modelos de pesquisa controlados

Essentially, peptides are amino acid strings that are naturally produced in the body

However, as fibrosis is a complex pathological event, ultimately resolving this complex pathology will require a multi-pronged approach that moves far beyond single-target drugs