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33 The in vitro study showed penetration and fast absorption of glutathione through reconstituted oral epithelium, from 55% after 10 min to about 70% after 30 min

In contrast, erastin failed to induce ferroptosis in our in vitro model, potentially because, as previously published, CLL cells are inherently limited in their ability to take up cystine under baseline conditions (Supplementary Fig

The protein: inhibitor complex was mixed in a 1:1 ratio (1 L protein: inhibitor complex and 1 L reservoir solution containing 100 mM sodium acetate pH 8.09.0, 200 mM Tris-HCl pH 8.09.0, 2535 % (w/v) PEG4000)

Each photo was processed through QuPath digital imaging as previously described to create a color gradient heat map to quantify the stain density standardized to control stains [31]

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