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Antioxid Redox Signaling 35 (14), 12071225

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When cultured from both young and elderly donors, CD34 + cells from young individuals predominantly developed into CD56 + CD16 NK cells, while cells from elderly individuals exhibited a CD56 CD16 + phenotype with lower cytotoxic activity

Although constant activation of the biosensor promoter during differentiation, applied here, prevented it from silencing, this in itself emphasizes the necessity to discover new safe harbors in the human genome (Fig