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we analyzed the relationship between the amount of infiltration of CD8+ and granzyme B+ cells, CD8+ and Tox/Tox2+ cells, and CD8+ and TIM-3+ cells and prognosis

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This supports our observation that the presence of positive/polar charged residues at this position interacting with negatively charged phosphorylation sites in the R-domain is important for proper functioning of this family of transporters (Supplementary Fig