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10.2147/IJN.S338886 197 ZhengS

Yahia EM, Garca-Sols P, Celis MEM

H., Estaras, C., Moresco, J

The MTHFR issue: Approximately 4060% of the population carries a variant in the MTHFR gene (most commonly the C677T polymorphism), which reduces the activity of the enzyme that converts synthetic folic acid into its active, usable form (5-methyltetrahydrofolate, or 5-MTHF)