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It thus bypasses the digestive system, during which its absorption or effectiveness may be reduced

Upregulation of TNF- , IL-1 , -6, -18, -23 and IFN- in MNPs, mesenchymal and epithelial cells is sustained by NF-kB, JAK/STAT, c-Jun N-terminal kinase (JNK) and p38 kinase signalling pathways [69]

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