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Results Inhibition of mitochondrial fat oxidation in skeletal muscle prevents a local inflammatory response in Cpt1b m/ mice Cpt1b m/ mice have elevated plasma lipids, and accumulation of both intramyocellular lipid (IMCL) and lipotoxic species such as DAG and ceramides, but they have lower fasting insulin and glucose, improved glucose tolerance, and no impairment of insulin signalling in skeletal muscle 23