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Recent studies have further clarified the biological basis for why gluten-containing wheat products exacerbate symptoms in some IBS patients

Opyrchal M,Cao S,Wan J,Zhang C,Zhang X

Specifically, a high-fat and high-sugar diet increased the -amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid to N-methyl-D-aspartic acid receptor current ratio in medium spiny neurons and prolonged spontaneous glutamate-mediated currents, increased DA release and slower DA reuptake in the striatum, and reduced MOR-mediated synaptic plasticity (73)