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10.1016/s0305-4179(03)00203-1 [DOI] [PubMed] [Google Scholar] Rao K

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Evening application also avoids daytime interactions with vitamin C serums and sunscreens

Reported headache symptoms may include: Persistent or severe headaches should always be discussed with a healthcare provider

User 15 cited a general dosing range of 2.5 to 3.75mcg per kilogram of body weight twice daily, which, at higher body weights, still produces doses within the standard 250 to 500mcg range being used across the dataset