chac1 glutathione Glutathione-specific gamma–glutamylcyclotransferase 1 (CHAC1) increases kidney disease risk by modulating ferroptosis Calcium channel mutants rescue the

Calcium channel mutants rescue the effect of glutathione depletion. (A) Download Scientific Diagram Glutathione (GSH) depletion by ChaC1 results in a more oxidizing Download Scientific Diagram Mitochondrial respiratory function is preserved under cysteine starvation via glutathione catabolism in NSCLC Nature Communications Identification of Juglone, a 'first in class' inhibitor of the human glutathione degrading enzyme, ChaC1, using yeast based high throughput screens bioRxiv CHAC1 degradation of glutathione enhances cystine starvation induced necroptosis and ferroptosis in human triple negative breast cancer cells via the GCN2 eIF2 ATF4 pathway Oncotarget

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