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Similar content being viewed by others Introduction Immunosenescence, a concept proposed by Roy Walford in the 1960s, refers to the progressive remodeling and decline of immune function with aging

Antioxidants 13 , 1201 (2024)

When paired with biochemical precursors and complementary antioxidants, they provide a more dependable, safer, and user-friendly option

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The simplistic and outdated two-hit hypothesis has been replaced by a multi-hit model that integrates various interconnected processes, as shown in Figure 2, where multiple factors act synergistically, encompassing lipotoxicity, gut dysfunction, altered gut-liver axis and innate immune activation, within the context of genetic and environmental factors (68)