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Furthermore, technologies such as microfluidics or flash nanoprecipitation should be explored as they offer greater control over nanoparticle size and composition to ensure consistent biological response and GMP compliance 145,148,149

2f) as well as DNA fragmentation in HepG2 cells pretreated with exogenous H 2 O 2 (Fig

The limits of passive targeting techniques are highlighted by thorough assessments of nanoparticle delivery efficiency, which have revealed that, on average, less than 1% of the injected nanoparticle dosage penetrates solid tumors [11, 12]