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FIGURE 6 4.4.1 Dynamic equilibrium and drug resistance of m 6 A modification m 6 A modification dynamically regulates RNA metabolism through the writer-eraser-reader ternary system: METTL3/WTAP complex recognizes the GGACU motif of RRM2 mRNA, adds an m 6 A mark to its 3UTR, recruits YTHDF2 reader, enhances mRNA stability and promotes translation (Zaccara et al., 2019)