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Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state

Pol J Food Nutr Sci 13:101114 Wilczewska AZ, Niemirowicz K, Markiewicz KH, Car H (2012) Nanoparticles as drug delivery systems

The enriched plasmid population that successfully expressed sufficient of the soluble factor in the conect body site for the desired time is then used as the starting population for another round of selection, incorporating gene reassembling (optionally in combination with other directed evolution methods described herein) to expand the diversity, if further improvement is desired

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doi: 10.1038/s41577-020-0305-6 49 ZhaoM