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Furthermore, we treated dividing and senescent cells with 20 M of CPP-CAND and assessed caspase 3/7 activity to examine whether the apoptosis observed was caspase-dependent

and increased TGF-/Smad pathway activity in POP fibroblasts (Jin et al

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FIGURE 2 Aging-associated increase in GSTM1 expression in the brain A recent study has reported that the expression level of GSTM1 in the hippocampus is associated with memory ability in 5xFAD mice, which harbors human mutations in the genes for amyloid precursor protein and presenilin one related to early-onset familial Alzheimers disease (Figure 3A)

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