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(1) Inhibition of macrophage phagocytosis by sUA.Research into HUA-induced atherosclerosis has suggested that macrophage overexpression of xanthine oxidoreductase (XOR) and heightened intracellular sUA concentrations activate macrophage phagocytosis

Pancreatic -cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota

This increased oxidative stress contributes to hepatocyte apoptosis and triggers inflammatory responses that promote fibrogenesis in MASLD

Bonomi M,Holst J,Schlessinger A

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability