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The short half-life of ADC in vivo is now a major obstacle in using it as an anti-cancer drug [159]

In many countries, they're already declining in population and the number of older people is just going up as a percentage, ready to bankrupt those countries

For instance, Isoyama et al

People exposed to nitrous oxide (medical or recreational use) may develop functional B12 deficiency, as the gas inactivates B12-dependent enzymes, potentially requiring supplementation