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In fact, pharmacologic weight management should be considered in patients who meet these weight criteria and have any of a number of chronic conditions in which obesity is considered to play a major role, including type 2 diabetes mellitus (T2DM), cardiovascular disease, hypertension, dyslipidemia, obstructive sleep apnea, nonalcoholic fatty liver disease, certain cases of malignancies (i.e

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Low serum B12 can mean that tissues are competing for limited holoTC in the bloodstream, and areas with high B12 turnover (including the bone marrow) may get priority, while the brain, liver and peripheral nerves do not receive enough

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