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Yes, youve already been on a GLP-1 medication, but tirzepatide works on two receptors instead of one, so your body needs time to get used to it

1999 Dec;112(12):1068-72

(source) Glykofrydi S, Kokkinos A, Barber TM, et al

Tebentafusp, a TCR/Anti-CD3 bispecific fusion protein targeting gp100, potently activated antitumor immune responses in patients with metastatic melanoma