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Administration of anthracyclines results in acute, early-onset, and delayed-onset cardiotoxicity, and the risk of developing heart failure increases as the cumulative doses increase, but in some cases, it can occur more than two decades after medication therapy has been completed

For example, the disulfide 23 (HA08) that comprises a 13-membered ring system, a -turn mimetic in the C-terminal and a -amino acid residue in the N-terminal ring system exhibits a Ki of 3.3 nM

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