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The effect of injected synthetic thymic peptides on T helper cell activity increased with an increase in the injected dose, but the efficiencies of THF-y2 and thymopentin were 400-fold and 8fold greater than that of thymosin aI, respectively." More recently, we investigated the production of cytokines, namely, interleukin2 (IL-2) and IL-4, by mitogen-stimulated spleen cells from aging mice when cultured with THF-y2 or a recombinant murine cytokine (IL-lp, IL-2, IL-3, IL-4, or IFN-y)