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8:e5077710.7554/eLife.50777 Elife Summary Keywords glutathione peroxidase 1, spiral ganglion neuron, peroxynitrite, oxidative stress, nuclear factor-kappa B, hearing loss Citation Wang X, Han Y, Chen F, Wang M, Xiao Y, Wang H, Xu L and Liu W (2022) Glutathione Peroxidase 1 Protects Against Peroxynitrite-Induced Spiral Ganglion Neuron Damage Through Attenuating NF-B Pathway Activation

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The upregulated proteins are enriched in the Gene Ontology (GO) 50 terms of collagen-containing extracellular matrix, perineuronal net, lysosome, glutathione metabolic process, etc

Differences between two groups were analyzed using unpaired Students t-test, while comparisons among multiple groups were performed using one-way analysis of variance (ANOVA) followed by Tukeys post hoc test for pairwise comparisons

Its effects have been linked to endothelial nitric-oxide synthase (eNOS) and to VEGFR2-driven angiogenesis, and its influence on fibroblast outgrowth and migration is attributed to the FAKpaxillin signaling pathway