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Studies have shown that the AKT inhibitor ipatasertib (Ipa) combined with TMZ, can significantly increase ferroptosis in IDH-mutant glioma cells ( Boric acid enhances the chemosensitivity of TMZ-resistant GBM cells by activating the ferritin autophagy pathway and disrupting cellular iron homeostasis

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Next, through RNA-seq and MeRIP-seq analyses, SLC7A11 was identified as a downstream target of FTO-mediated m6A modification, which was further confirmed by luciferase and western blot analysis in control and FTO over-expression/knockout PTC cells

Catalase (CAT) and glutathione peroxidase (GPH) catalyze the breakdown of hydrogen peroxide and lipid hydroperoxides, respectively, thereby preventing the formation of additional reactive oxygen species