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After three months of HFD feeding, magnetic resonance imaging (MRI) analysis revealed that Gpr146 / male mice had significant less fat mass than wild type controls (Fig

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Considering that OLFM4 can bind pan-cadherin 35 and that FAT1 is a nonclassical cadherin protein which previously identified as a key upstream regulator of the Hippo pathway 28,55 , we speculated that OLFM4 may regulate the activity of upstream Hippo signaling through FAT1