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Limited data from animal models of cancer found that -tocopheryl succinate administered by injection inhibited tumor growth (118)

J Paediatr Child Health

Atherosclerosis as pathogenetic substrate for Sars-Cov 2 cytokine storm

In the lungs, after entering in type II alveolar cells, SARS-CoV-2 infected cells become defective for surfactant production (Ghati et al., 2021) and release cytokines, like IL-8 among others, which in turn activate alveolar macrophages to release IL-1, IL-6, and TNF-, that induce natural killer and dendritic cell differentiation and macrophage M1 polarization, enhancing the proinflammatory response with increased vasodilation causing neutrophil and activated T cell influx from the capillaries into the alveolus, all leading to the cytokine storm (Carcaterra and Caruso, 2021

In Figure 2, we have stated potential DNA repair mechanisms related to each of IMMETCOLS subtypes