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During the cystine plus gentamicin assay, we observed that the optimal concentration of cystine needed to enhance the bactericidal action of gentamicin varied across strains

This effect was further corroborated in an in vitro study, where high doses of GH were found to be harmful to rat preantral follicle survival, possibly due to excessive theca and stromal cell proliferation and subsequent nutrient depletion (35)