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Although LB density seemed normal in KP with and without FLG mutations, all KP patients displayed aberrant LB internal structures, suggesting defective loading of lipid contents into the organelles of the keratinocytes

In the present study we have examined GSH changes using the most common rodent exposure regimen for chronic CS studies and have shown that there is a GSH adaptive response to CS that occurs very early on and can be maintained for periods of up to 4 months

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Eight (32%) cases emerged between 12 - 18 months, 3 (12%) patients developed epilepsy between 18 - 24 months, and 2 (8%) patients had their first seizures more than 24 months later