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Science 304 , 11581160 (2004)

Changes in fluorescence intensity in collected green images were measured using a customized application (ZEN, blue edition)

These effects promote increased neuroplasticity and modulate the neurotransmitters glutamate, dopamine, gamma-aminobutyric acid (GABA), acetylcholine, and glycine [118]

In summary, pH responsive hydrogels leverage the mildly acidic milieu of osteoarthritic joints to achieve lesion preferential drug release via pH driven swelling or deswelling and cleavage of acid labile linkages, thereby supporting anti-inflammatory and antioxidant therapy