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To estimate changes in lipid peroxidation, we assayed MDA via the thiobarbituric acid reactive substance assay

379,380 A phase I clinical trial in which pazopanib and vorinostat were combined to treat patients with p53-mutant tumors suggested that HDAC inhibitors can abolish the proangiogenic function of mutant p53

Neurology 44, 14111417

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Furthermore, long-term studies with extended observation periods, doseresponse profiling, and pharmacokinetic evaluation will be necessary to establish optimal dosing regimens and assess clinical safety