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Previous work has reported relatively increased Firmicutes and Proteobacteria and decreased Bacteroidetes in mice on an HFD, regardless of concomitant obesity (weight gain was minimized using a RELM knockout mouse 78 ) 78,79

However, a significant number of variants detected in patients with cholestatic liver disease fall into the VUS category, where it remains unclear whether the variant contributes to the patients phenotype [68]

63 Other SOD mimetics such as the manganese metaloporphyrin AEOL-10113 decrease murine airway inflammation and hyperreactivity, 64 whereas AEOL-10150 decreases cigarette smoke-induced pulmonary inflammation

Another potential but very rare source is hemolysis from packed red blood cells (PRBCs) transfusion 35

The histology of lumbar intervertebral disc herniation